SpacePharma’s Experiments in Microgravity
OUR miniaturized ISS labs
SpaceX CRS-30
mAb crystallization technology demonstration
SpacePharma launched its sixth microgravity lab to the ISS on board the SpaceX vehicle, with the experiment returning to earth in April 2024.
Launched
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March 2024
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Figure 1 SpacePharma Advanced lab (SPAd) on board of the ISS
OUR miniaturized ISS labs
NG-19
Prion disease research mission
SpacePharma launched its fifth microgravity lab to the ISS on board of the Northrop Grumman Cygnus spacecraft, with the experiment returning to earth in September 2023.
Launched
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August 2023
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Figure 1 NG-19 mission patch
OUR miniaturized ISS labs
SpaceX CRS-27
The newest successful experiment onboard the ISS
SpacePharma launched its fourth microgravity lab to the ISS on board SpaceX vehicle, the experiment returned to earth on April 2023.
Launched
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March 2023
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Figure 1 SpacePharma Advanced lab (SPAd) being prepared for the CRS-27 mission
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Figure 2 CRS-27 SpaceX Dragon loaded with SpacePharma's experiments ready for launch to space
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Figure 3 SpaceX CRS-27 launching SpacePharma's SPAd to the ISS
Skin Tissue in Space
cultivation of human skin cells (keratinocytes and fibroblasts) in 2D or 3D culture systems to assess their ability to produce extracellular matrices, and also look at the cells’ properties, such as proliferation and their ability to migrate. The aim is to deepen the understanding of fundamental biological processes and potentially support the development of new therapies, devices and tools for wound healing, aging, and scarring.
Nanoemulsions
Production of phyto-nanoemulsion of a well-known plant under microgravity. This unique environment will potentially create a stronger therapeutical effect and a high stability for the final product, as emulsion properties are enhanced in microgravity, for example coalescence is much slower.
OUR miniaturized ISS labs
SPAd 2
5th generation lab onboard the ISS
SpacePharma launched its third microgravity lab to the ISS on board of SpaceX Axiom1 mission and returned to earth on April 25th 2022.
Launched
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April 2022
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Figure 1 Israeli astronaut Eytan Stibbe unloading SpacePharma's SPAd system for operations on the ISS
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Figure 2 SPAd-lab and first private space mission Axiom-1 patch
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Figure 3 SpaceX Dragon on the Axiom-1 mission arriving to the ISS carrying SpacePharma's SPAd
Meat for Space
Examining the ability of cow cells to mature into cells that build muscle tissue, the steak, under microgravity conditions
Interrogation of the Stress and DNA Damage Response During Space Flight
The purpose was to explore the effect of both magnetic field and microgravity. Apparently in parabolic flight no significant differences were observed.
Polymorphism of Organic Crystals
Crystallization of Histidine was performed in a flow system by adding antisolvent, in timing with airplane dives. Higher tendency towards the more stable polymorph A in flight, compared to Higher tendency towards the less stable polymorph B on ground was observed. It Indicates that initial seeding in microgravity determines polymorph of entire crystal population.
OUR miniaturized ISS labs
SPAd
SpacePharma advenced lab at the ISS
Launched
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December 2021
The third microgravity lab to the ISS on board of SpaceX SPX-24 and returned to earth on January 24th 2022, in collaboration with Ramon Foundation.
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Figure 1 SpacePharma SPAd on the ISS during the CRS-24 mission
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Figure 2 SpacePharma CEO Yossi Yamin with the SPAd prior to handover for the CRS-24 mission
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Figure 3 SpaceX Dragon approaching the ISS on the CRS-24 mission carrying SpacePharma's SPAd
M&M - Metformin and Muscles
Effect of microgravity on the regeneration process of human skeletal muscles cells.
Motor Neurons
Study the effect of microgravity on gene expression in the destruction process of motor neurons cells
Biomechanical Effects on the Interactions of Cancer Cells with Nano Carriers
Explore the biomechanical characteristics of cancer cells and the effect of antitumor drugs loaded in nanocarriers (Doxil liposomes) under microgravity conditions.
The Effect of Sub-gravity on Malignant Cells
Changes in RNA expression in Jurkat cancer cells (T-ALL cell line) exposed to microgravity
OUR SATELLITEs
DIDO 3
Free orbit satellite
Launched
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SEP 2020
The Second free orbit autonomous and remoted controlled nanosatellite was launched including 4 scientific experiments for Israeli and Italian Universities and Hospitals.
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Figure 2 SPmg2 lab ready to be installed in DIDO2 satellite
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Figure 3 Droplet coalescence during 10 days experiment
Human serum albumin binding properties
investigate the heme binding to HSA in microgravity conditions as a prototypical model to establish whether gravity may affect the HSA capability to bind endogenous and exogenous molecule
Enzymatic Reaction
Investigate how microgravity environment of space affects the kinetics of the action of antimicrobial agents on bacterial pathogens
Antibiotic resistance
Bacterial conjugation, dissemination of antibiotic resistance genes and their expression control under microgravity conditions
DNA structure
Reconfiguration of DNA structures and their functions under no gravity conditions
